High Quality Ingredients, Backed by Science
Our products contain unique blends of scientifically-researched vitamins, minerals, amino acids, prebiotics, live cultures and phytonutrients from some of the world’s most well-regarded nootropics, including botanicals from various pillars of herbal medicine.
They're designed to support normal focus₁, wellbeing₂, energy₃, cognition₄, memory₄, antioxidant₅ protection and mental performance₆.
A Proud HFMA Member
As a member of the HFMA, our products are recognised and backed by the largest food safety organisation in the UK.
All Our Ingredients, Backed by Science
Magnesium
Magnesium is involved in over 600 enzymatic bodily processes. It is involved in the electrical activity of neuronal (brain) cells, and research associates low levels with neuronal excitation, hyperactivity, lack of focus and low mood. Magnesium malate, a combination of magnesium and malic acid, is often used to support mental performance and energy, given malic acid’s role in production of mitochondrial energy – energy produced by our cellular “powerhouses”. It has often been used for chronic fatigue and mental and physical endurance.
The Research:
- https://pubmed.ncbi.nlm.nih.gov/20152124/
- https://pubmed.ncbi.nlm.nih.gov/32503201/
- https://pubmed.ncbi.nlm.nih.gov/30807974/
- https://pubmed.ncbi.nlm.nih.gov/32503201/
- https://pubmed.ncbi.nlm.nih.gov/23808779/
- https://pubmed.ncbi.nlm.nih.gov/30496768/
- https://pubmed.ncbi.nlm.nih.gov/9368235/
- https://pubmed.ncbi.nlm.nih.gov/28445426/
- https://pubmed.ncbi.nlm.nih.gov/9368236/
- https://pubmed.ncbi.nlm.nih.gov/20868469
- https://pubmed.ncbi.nlm.nih.gov/32035071/
- https://pubmed.ncbi.nlm.nih.gov/26138554/
- https://pubmed.ncbi.nlm.nih.gov/29920022/
B Vitamins
Whilst each B Vitamin has their own important role, it is generally accepted that they can function synergistically together to support nervous system function and neuro-wellbeing. B Vitamins have wide-ranging roles, including the synthesis and regulation of neurotransmitters, metabolism of nutrients into energy for the brain and cognition (e.g. learning, focus, attention), involvement in the stress response (e.g. resilience to stress), production of key enzymes, gene expression and more.
B1: Vitamin B1 (Thiamine) is an essential vitamin involved in the production of energy from food, and plays a neuro-modulatory role in the production of key neurotransmitters, acetylcholine (involved in learning, memory and cognition) and dopamine (involved in focus, attention and motivation). It also contributes to the function and structure of neuronal cell membranes. Deficiency has been linked with various neurological issues, including fatigue, confusion, memory loss, cognitive deficits and even dementia.
B2: Vitamin B2 (Riboflavin) is involved in the production of essential compounds FAD and FMN, critical for energy metabolism, including in the brain. It also has a role in mitochondrial (cellular batteries) function, and may have neuroprotective effects given its role in reduction of oxidative stress (which may contribute to migraines). It is also involved in the synthesis and recycling of other B-vitamins, and production of haemoglobin and enzymes involved in nitric oxide which impact oxygen transport and storage, including to the brain.
B3: Vitamin B3 (Niacin, Nicotinamide) is vital in supporting normal function of various enzymes involved in cellular processes in both body and brain. It is key for the production of cellular molecule NAD+ which is involved in metabolising food into energy, regulating cellular function, reducing mitochondrial damage and protecting cells, so is associated with increased cognition and longevity. It has been associated with various neuropsychiatric conditions.
B5: Pantothenic Acid is often regarded for its involvement in the stress response. Involved in the synthesis of Co Enzyme CoA, it plays a role in metabolism, the production of various structural components vital to healthy neuronal (brain) cells, and in the synthesis of multiple neurotransmitters, including acetylcholine (associated with focus, learning, memory, recall and brain fog), serotonin (well-known for its role in mood) and epinephrine (involved in the stress response). It is key for normal brain function, cognition and neuro-wellbeing.
B6: Pyridoxal-5-Phosphate: is mostly known for its role in cognitive function, being involved in the synthesis of multiple neurotransmitters, including dopamine (motivation, attention), serotonin (mood), γ-aminobutyric acid (GABA – known for its nervous system-calming effects) , noradrenaline (attention, alertness) and melatonin (sleep). It is also a key co-factor in the activation of Folate, Vitamin B6 and in the metabolism of various amino acids. Research suggests deficiencies may be associated with cognitive challenges, alongside lower levels of GABA and serotonin, which may impact sleep and wellbeing.
B7: Biotin is more well-known for its role in hair, skin and nails, but actually has a wider-ranging role. It is involved in glucose metabolism - from initial uptake to conversion into a usable form of energy – Adenosine Triphosphate (ATP) - the brain’s main energy source. Research has associated biotin deficiencies with alteration in functions of learning and memory, perhaps due to an impact on dopamine.
B9: Folate and B12: Cobalamin: B9 and B12 are linked due to their complementary roles in the folate and methionine cycles.
B12 is required for activation of B9 (folate), so low levels of B12 result in low active levels of B9 (which remains as inactive methyl-tetra-hydro-folate). This impacts a process called methylation, which has a profound impact on various bodily processes. Methylation is, for example, involved in energy production, cognition, neurotransmission (brain communication), genetic expression (e.g. DNA repair) and neuronal differentiation (involved in brain development).
B12 also plays wide-ranging roles in brain structure and function, with research associating deficiencies with impact on memory, mood, cognition and energy.
Active B9 (folate) is also involved in various processes, including synthesis of serotonin (well-known for its impact on mood), melatonin (associated with sleep), dopamine (involved in motivation, focus and reward-seeking behaviour), noradrenaline and adrenaline (involved in the stress response, e.g. alertness), and nitric oxide (impacting blood vessel dilation and storage / transport of oxygen around the body).
The Research
Vitamin D3
The active form of Vitamin D, is one of the 24 nutrients that is critical for survival. Alongside playing a role in cell division, muscle function, bone and skin health and immunity, Vitamin D plays a key role in brain physiology, namely in regulating synaptic plasticity - the brain’s ability to learn throughout life, form and consolidate new memories. It impacts various cognitive processes, and research has studied the link between Vitamin D and various neuropsychiatric conditions.
The Research
Bacopa Monnieri
This botanical has been used for centuries by Ayurvedic medical practitioners for use in cases of stress, anxiety, and challenges with memory and cognition. Bacaopa Monnieri impacts the dopamine and serotonin pathways in the brain, which are impacted in conditions of inattention, hyperactivity, learning, memory and cognition, so has been utilised in a range of conditions, from ADHD to Alzheimer's Disease. It also plays a role in neurotransmission - brain communication - so may be useful in supporting overall cognition and mental performance.
The Research:
https://pubmed.ncbi.nlm.nih.gov/24252493/
https://pubmed.ncbi.nlm.nih.gov/35592415/
https://pubmed.ncbi.nlm.nih.gov/22747190/
https://pubmed.ncbi.nlm.nih.gov/34978226/
Prebiotics & Probiotics
There is a complex relationship between the microbiota (inhabiting bacteria) within the gastrointestinal tract (GIT) and the central nervous systems (CNS), with consistent two-way communication taking place between the gut and the brain (also involving and impacting the vagus nerve, the endocrine / hormonal system, and immune system). A plethora of research indicates the microbiome (community of bacteria) in the gut is often altered in an array of psychiatric conditions, including those impacting cognition and mood.
The Gut-Brain-Axis can be modified via particular probiotics (live cultures), prebiotics (fibre, which feeds probiotics) and digestive enzymes (which support the digestion and fermentation of foods, and may be helpful in relieving problems associated with mal-digestion). Together, research suggests these “psychobiotics” may have a wide-ranging impact in mental health, cognition and overall neuro-wellbeing (alongside gastrointestinal upset!).
The Research:
https://pubmed.ncbi.nlm.nih.gov/12056881/
https://pubmed.ncbi.nlm.nih.gov/35048732/
https://pubmed.ncbi.nlm.nih.gov/34524405/
https://pubmed.ncbi.nlm.nih.gov/32684346/
https://pubmed.ncbi.nlm.nih.gov/33198044/
https://pubmed.ncbi.nlm.nih.gov/34271306/
https://pubmed.ncbi.nlm.nih.gov/31016507/
https://pubmed.ncbi.nlm.nih.gov/35360098/
https://pubmed.ncbi.nlm.nih.gov/35887166/
https://pubmed.ncbi.nlm.nih.gov/27413138/
https://pubmed.ncbi.nlm.nih.gov/32192218/ *
https://pubmed.ncbi.nlm.nih.gov/34271306/
https://pubmed.ncbi.nlm.nih.gov/35477082/
https://pubmed.ncbi.nlm.nih.gov/31096437/
https://pubmed.ncbi.nlm.nih.gov/33198044/
https://pubmed.ncbi.nlm.nih.gov/35887166/
https://pubmed.ncbi.nlm.nih.gov/34620373/
https://pubmed.ncbi.nlm.nih.gov/34171323/
https://pubmed.ncbi.nlm.nih.gov/34942539/
Phosphatidylserine
Phosphatidylserine (a type of phospholipid) is a fatty substance which is highly prevalent in brain tissue. It has a structural role in healthy neuronal brain cells, including in neurotransmission - brain cell communication. It is key in cognition, playing a role in formation of short-term memories, long-term memories, recall, focus, attention, and various other cognitive skills.
The Research:
Acetyl L-Carnitine
Acetyl L-Carnitine is one of the few compounds which can efficiently cross the blood-brain-barrier. It facilitates entry of fatty acids into the body’s mitochondria (cellular powerhouses) to help regulate energy (for example, mental energy and cognition) and increases the levels of the neurotransmitter acetylcholine, involved in processes of memory, learning, neuroplasticity (the brain’s ability to learn through life) and overall cognition. It may also be involved in mood.
The Research:
https://pubmed.ncbi.nlm.nih.gov/24350200/
https://pubmed.ncbi.nlm.nih.gov/12598816/
https://pubmed.ncbi.nlm.nih.gov/21263444/
Choline
Choline has a structural role in brain cell membranes, important for developmental processes. It is also essential in the formation of the neurotransmitter acetylcholine, involved in processes of cognition, learning, memory and overall mental function.
The Research:
https://pubmed.ncbi.nlm.nih.gov/36041182/
https://pubmed.ncbi.nlm.nih.gov/34201092/
https://pubmed.ncbi.nlm.nih.gov/34201092
https://pubmed.ncbi.nlm.nih.gov/32531929/
https://pubmed.ncbi.nlm.nih.gov/26179181/
https://pubmed.ncbi.nlm.nih.gov/8624220/
https://pubmed.ncbi.nlm.nih.gov/25681529/
https://pubmed.ncbi.nlm.nih.gov/33053828/
Pine Bark Extract
Pine Bark Extract, otherwise known as Pycnogenol, contains various bioactive compounds such as phenolic acids, catechin and procyanidins which research suggests may impact processes of inflammation, oxidation and cognition. It is also involved in synthesis of nitric oxide, which acts as a neurotransmitter in brain communication and is involved in dilation of blood vessels and blood flow - including to the brain.
The Research:
https://pubmed.ncbi.nlm.nih.gov/29713620/
https://pubmed.ncbi.nlm.nih.gov/35592415/
https://pubmed.ncbi.nlm.nih.gov/33559134/
https://pubmed.ncbi.nlm.nih.gov/32204500
- https://pubmed.ncbi.nlm.nih.gov/24675223/
Alpha-Lipoic Acid (ALA)
Alpha-Lipoic Acid (ALA) is an antioxidant compound used extensively by mitochondria - the body’s cellular “powerhouses”, which are responsible for turning foods into a usable form of energy (ATP). ALA acts as an enzymatic cofactor in the production of energy, in enzymatic and mitochondrial function and in metabolism. It is also a potent antioxidant which impacts inflammation, oxygen flow (including to the brain), and which research suggests may be helpful in memory and cognition.
The Research:
https://pubmed.ncbi.nlm.nih.gov/35445914/
Green Tea
Used in Asian cultures, Green Tea has been utilised for centuries for its impact on memory, learning, overall cognition and for antioxidant and longevity-enhancing properties. It has also been researched with regard to its impact on blood vessel dilation and blood flow – including to the brain. L-Theanine, one of the main components of interest in green tea, is one of the few compounds that can cross the blood-brain barrier, and has been the focus of research regarding its anxiolytic properties, namely due to its ability to modulate inhibitory neurotransmitters, including GABA, serotonin, and dopamine. L-Theanine has also been researched for its impact on cognition, focus and on alpha brain wave activity.
The Research:
https://pubmed.ncbi.nlm.nih.gov/28899506/
https://pubmed.ncbi.nlm.nih.gov/24946991/
https://pubmed.ncbi.nlm.nih.gov/35111479/
Coenzyme Q10
Coenzyme Q10 (COQ10) is a molecule produced in the body. It aids mitochondria during energy production and is part of the body’s own antioxidant system. It assists the cells’ mitochondria (cellular powerhouses) in the conversion of nutrients into usable energy (ATP), the brain’s main form of energy. It also preserves levels of nitric oxide, which supports blood vessel dilation and transportation of oxygen around the body, including the brain. CoQ10 is also involved in protecting mitochondria and brain cells from oxidative damage and dysfunction. Research into CoQ10 has looked at a potential correlation between low CoQ10 and cognitive challenges.
The Research:
https://pubmed.ncbi.nlm.nih.gov/36091835/
https://pubmed.ncbi.nlm.nih.gov/27149984/
Betaine
Betaine (also known as trimethylglycine) is a metabolite of choline, a key cellular component of the brain. It plays a key role as a methyl donor in the brain during a process called “methylation” which impacts the turning on / off of various genes; activation of key nutrients, including folate; regulation of multiple neurotransmitter pathways involved in attention, memory and motivation; downregulation of inflammatory homocysteine; and is also a structural component in cellular membranes. Choline is also a precursor for acetylcholine synthesis, a neurotransmitter involved in learning, memory, cognition and motivation.
The Research:
Taurine
Taurine is an amino acid found abundantly in the brain, and has various cellular functions, including a central role as a neurotransmitter, as a trophic factor (trophic generally meaning growth, development and survival) in nervous system development, in the structural integrity of cell membranes and is involved in the process of neurotransmission (brain communication) amongst other roles. It is also known to have antioxidant properties. Taurine has been researched for its various properties regarding brain communication, memory, mood and cognition, including its impact on nervous-system calming neurotransmitter GABA and on synapse formation, which is involved in the process of neurotransmission (brain communication). Research has associated low taurine with various neuropsychiatric conditions.
The Research:
Panax Ginseng
Panax Ginseng, also known as Asian ginseng, Chinese ginseng and Korean ginseng, is an ancient botanical that has been widely used in Traditional Chinese and Ayurvedic Medicine for centuries for memory, learning, cognition, mood and energy. Its active compounds include ginsenosides and panaxosides which have been studied in relation to antioxidant, immune, inflammatory and cell-protective properties. It has also been researched with regard to its impact on nitric oxide, which has vasodilating properties and impacts blood flow. It is also considered an “adaptogen”, defined as a natural substance considered to help the body adapt to stress.
The Research:
https://pubmed.ncbi.nlm.nih.gov/32765262/
https://pubmed.ncbi.nlm.nih.gov/19584437/
https://pubmed.ncbi.nlm.nih.gov/21704950/
L-Tyrosine
L-Tyrosine is an amino acid involved in the production of several important catecholamine neurotransmitters, including dopamine, which impacts areas such as attention, focus and reward-seeking behaviour. It is also involved in the production of Noradrenaline (known to impact alertness, arousal and attention). L-Tyrosine has been studied for its impact on cognition during stress and ageing.
The Research:
Vitamin C
Vitamin C is well-known for its antioxidant status and ability to support the normal functioning of the immune system, but many people are not aware of its ability to also support normal functioning of the psychological system, the nervous system, support normal energy-yielding metabolism, contribute to reduction of tiredness and fatigue and protect cells from oxidative stress – amongst other functions. Vitamin C is also involved in the formation of collagen (which is also a key component of health blood vessels, including those in the brain), formation of L-Carnitine (involved in mitochondrial energy and cognition) and in the production of various neurotransmitters, including noradrenaline (associated with alertness and attention) and dopamine (known for its involvement in motivation and focus). Vitamin C is used by the body in large quantities during times of stress, and research has studied the relationship between Vitamin C, stress and neuropsychiatric disorders.
The Research:
The Gut-Brain-Axis
There is a complex relationship between the microbiota (inhabiting bacteria) within the gastrointestinal tract (GIT) and the central nervous systems (CNS), with consistent two-way communication taking place between the gut and the brain (also involving and impacting the vagus nerve, the endocrine / hormonal system, and immune system). A plethora of research indicates the microbiome (community of bacteria) in the gut is often altered in an array of psychiatric conditions, including those impacting cognition and mood.
The Gut-Brain-Axis can be modified via particular probiotics (live cultures), prebiotics (fibre, which feeds probiotics) and digestive enzymes (which support the digestion and fermentation of foods, and may be helpful in relieving problems associated with mal-digestion). Together, research suggests these “psychobiotics” may have a wide-ranging impact in mental health, cognition and overall neuro-wellbeing (alongside gastrointestinal upset!).
The Research:
https://pubmed.ncbi.nlm.nih.gov/12056881/
https://pubmed.ncbi.nlm.nih.gov/35048732/
https://pubmed.ncbi.nlm.nih.gov/34524405/
https://pubmed.ncbi.nlm.nih.gov/32684346/
https://pubmed.ncbi.nlm.nih.gov/33198044/
https://pubmed.ncbi.nlm.nih.gov/34271306/
https://pubmed.ncbi.nlm.nih.gov/31016507/
https://pubmed.ncbi.nlm.nih.gov/35360098/
https://pubmed.ncbi.nlm.nih.gov/35887166/
https://pubmed.ncbi.nlm.nih.gov/27413138/
https://pubmed.ncbi.nlm.nih.gov/32192218/
https://pubmed.ncbi.nlm.nih.gov/34271306/
https://pubmed.ncbi.nlm.nih.gov/35477082/
https://pubmed.ncbi.nlm.nih.gov/31096437/
https://pubmed.ncbi.nlm.nih.gov/33198044/
https://pubmed.ncbi.nlm.nih.gov/35887166/
https://pubmed.ncbi.nlm.nih.gov/34620373/
https://pubmed.ncbi.nlm.nih.gov/34171323/
https://pubmed.ncbi.nlm.nih.gov/34942539/
MA UKCP Psychotherapist
Emma Cohn
There is a mental health crisis and the NHS are understandably overwhelmed and challenged coping the diagnosis backlog. With long waiting times and often people not meeting the threshold to get initial appointments, this leaves a lot of people having to cope alone. Even if they are fortunate enough to be assessed by a psychiatrist and receive treatment, medication is often suggested and side effects may vary from person to person.
I have worked with many neurodivergent people who are experiencing challenges. A natural supplement that is accessible to all could be life changing to many people and I am very much looking forward to Divergence Supplements launching.
Further Information
- Contains Vitamin C, Vitamin B1, Niacin (Vitamin B3), Vitamin B6, Biotin, Folate (Vitamin B9), Vitamin B12 and Magnesium, which contribute to normal functioning of the psychological system.
- Contains Vitamin C, Vitamin B1, Vitamin B2, Niacin (Vitamin B3), Vitamin B6, Biotin, Vitamin B12 and Magnesium, which contribute to normal functioning of the nervous system.
- Contains Vitamin C, Vitamin B1, Vitamin B2, Niacin (Vitamin B3), Pantothenic Acid (Vitamin B5), Vitamin B6, Folic Acid (Vitamin B9), Vitamin B12 and Magnesium, which contribute to the reduction of tiredness and fatigue.
- Contains Zinc which contributes to normal cognitive function.
- Contains Vitamin C, Vitamin B2 and Zinc, which contribute to the protection of cells from oxidative stress.
- Contains Pantothenic acid (Vitamin B5), which contributes to normal mental performance.
